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Amphotericin B

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Product Overview
Product Name Amphotericin B
CAS1397-89-3
FormulaC47H73NO17
MW924.08
Product details

两性霉素B 原料药

【英文名称】:Amphotericin B
【中文名称】:两性霉素B
【中文同义词】:两性霉素 B 三水合物;水溶两性霉素 B;两性霉素B(标准品);两性霉素B 来源于链霉菌 属;两性霉素 B 溶液;可溶性两性霉素;庐山霉素;多烯抗生素
【CAS号】:1397-89-3
【分子式】:C47H73NO17
【分子量】:924.08
【EINECS号】:215-742-2


两性霉素B 性质
【熔点】:>170°C
【比旋光度】:D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl)
【沸点】:804.34°C (rough estimate)
【密度】:1.34
【颜色】:yellow
【形态】:powder
【酸度系数(pKa)】:pKa ~5.7(DMF/H2O) (Uncertain)
【水溶解性】:<0.1 g/100 mL at 21 oC
【化学性质】:淡黄色至橙黄色针状结晶或粉末。不溶于水、乙醇,溶于酸性DMF、DMSO,微溶于DMF、酸性或碱性含水低级醇。无臭,几乎无味。易被光、热和酸破坏。

【用途】:该品对多种真菌感染,如对新型隐球菌、白色念珠菌、荚膜组织胞浆菌、皮炎牙生菌、申克氏孢子丝菌、毛霉菌和粗球孢子菌等均有强大的抑制作用或杀灭作用。该品主要用于深部真菌病的首选药。



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